Seperating the Components of Panacetin

Alex Wilson 9/11/12 Experiment #2 Separating the Components of Panacetin: Introduction: Of the three components likely to be present in your sample of Panacetin (aspirin, acetanilide, and starch), only starch is insoluble in the organic solvent dichloromethane (or methylene chloride), CH2 Cl2. If a sample of Panacetin is dissolved as completely as possible in dichloromethane, the insoluble starch can be filtered out, leaving acetanilide and aspirin in solution. The purpose of this experiment is to extract the components of Panacetin.

Although the acetanilide and aspirin are both quite insoluble in water at room temperature, the sodium salt of aspirin is very soluble in water but insoluble in dichloromethane. Because aspirin is a reasonably strong acid, it can be converted to the salt, sodium acetylsalicylate, by reaction with the basic sodium hydroxide. While the two layers are thoroughly mixed, the aspirin will react with the sodium hydroxide in the bottom layer, which then migrates to the aqueous layer and can be easily separated in a separatory funnel.

Adding some dilute hydrochloric acid to the aqueous solution restores free aspirin as an insoluble white solid; evaporating the solvent from the bottom layer leaves the acetanilide behind. Experimental: For the separation of sucrose, we weighed out 3. 048g of Panacetin onto a filter, and 50 mL of dichloromethane in a graduated cylinder. Then we transferred both the panacetin and dichloromethane into an Erlenmeyer flask and stirred it until the panacetin was dissolved. We let it dry by gravity and set it aside to dry. The filter paper weighed about 1. 320g and sucrose weighed out at 1. 028g.

Sucrose also ended up on the outside rim of the filter paper. We then proceed to separate the aspirin. We measured 30mL of NaHCO3 and mixed it with 7mL of 6M HCl. We drained the organic layer into a pre-weighed Erlenmeyer flask and save it for recovery of acetanilide. We took the combined aqueous extracts in an Erlenmeyer flask, and acidify the aqueous solution by slow addition, with stirring, of 20 mL of 6M HCl. We made sure the solution is strongly acidic by testing it with litmus paper getting a pH of 2. We then cooled the mixture to room temperature swirling the flask occasionally in an ice bath.

We collected the aspirin by vacuum filtration and washed the aspirin on the filter with cold distilled water. We let it air dry for 30-35 minutes and then weighed the aspirin. It weighed out at 0. 513g. The unknown component was calculated and weighed at 0. 738g. Results: When we were mixing the filtration and letting it vent periodically, we lost some of it. So our percent recovery is as follows: The unknown component weighed 0. 738g. And our percent composition is as follows: Discussion: Sucrose is insoluble in the organic solvent dichloromethane (CH2 Cl2).

Aspirin, acetanilide, and phenacetin are soluble in dichloromethane but relatively soluble in water. Aspirin reacts with bases such as sodium bicarbonate to form a salt, sodium acetylsalicylate, which is insoluble in water. Acetanilide and phenacetin are not converted into salts by sodium bicarbonate. The Reciprocal (Interconversion) of Aspirin and it’s Sodium Salt Conclusion: The breakdown of Panacetin: Mix panacetin with CH2 Cl2 and you will get a solid which is sucrose and you’ll get a filtrate of aspirin and an unknown substance. Then you will extract the aspirin with NaHCO3 to get an organic layer and a water layer.

The bottom layer for us was the organic layer, while the top layer was the water layer. After figuring out the organic layer you mix the unknown with CH2 Cl2, and then you will evaporate to leave just the unknown substance. When you figure out which layer was the water layer, you’ll mix sodium salicylate and H2O. You will then add HCl until the pH level of the solution reaches 2. After the pH reaces2, you have aspirin; which proves that as long as you follow the directions in this lab, you will have indeed separated the aspirin from the panacetin.

Calculate the price
Make an order in advance and get the best price
Pages (550 words)
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
How it works
Receive a 100% original paper that will pass Turnitin from a top essay writing service
step 1
Upload your instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Pro service tips
How to get the most out of your experience with MyStudyWriters
One writer throughout the entire course
If you like the writer, you can hire them again. Just copy & paste their ID on the order form ("Preferred Writer's ID" field). This way, your vocabulary will be uniform, and the writer will be aware of your needs.
The same paper from different writers
You can order essay or any other work from two different writers to choose the best one or give another version to a friend. This can be done through the add-on "Same paper from another writer."
Copy of sources used by the writer
Our college essay writers work with ScienceDirect and other databases. They can send you articles or materials used in PDF or through screenshots. Just tick the "Copy of sources" field on the order form.
See why 20k+ students have chosen us as their sole writing assistance provider
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Business and administrative studies
Customer 452773, February 23rd, 2023
Social Work and Human Services
Great work I would love to continue working with this writer thought out the 11 week course.
Customer 452667, May 30th, 2021
Thank youuuu
Customer 452729, May 30th, 2021
English 101
great summery in terms of the time given. it lacks a bit of clarity but otherwise perfect.
Customer 452747, June 9th, 2021
Business and administrative studies
excellent work
Customer 452773, March 12th, 2023
I just need some minor alterations. Thanks.
Customer 452547, February 10th, 2021
thank you so much
Customer 452749, June 10th, 2021
Business and administrative studies
excellent job
Customer 452773, March 12th, 2023
Business and administrative studies
Thank you for your hard work
Customer 452773, October 19th, 2023
Business and administrative studies
always perfect work and always completed early
Customer 452773, February 21st, 2023
Business and administrative studies
Customer 452773, February 23rd, 2023
Business and administrative studies
excellent, got a 100
Customer 452773, May 17th, 2023
Customer reviews in total
Current satisfaction rate
3 pages
Average paper length
Customers referred by a friend
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat

Sometimes it is hard to do all the work on your own

Let us help you get a good grade on your paper. Get professional help and free up your time for more important courses. Let us handle your;

  • Dissertations and Thesis
  • Essays
  • All Assignments

  • Research papers
  • Terms Papers
  • Online Classes
Live ChatWhatsApp