The ability to identify independent and dependent variables, and determine if these variables are…

The ability to identify independent and dependent variables, and determine if these variables are discrete or continuous is critical to statistical testing. In the examples listed below, identify the following:
Is there an independent variable? Is this independent variable continuous or discrete? What is the dependent variable? Is this dependent variable continuous or discrete?

a. During a clinical trial, volunteers were randomly divided into two groups and administered either: 1) the Innovator antipsychotic medication or 2) Acme Chemical generic equivalent of the same drug. Listed below are the results of the trial (Cmax). Is there any difference between the two manufacturers’ drugs based on this one pharmacokinetic property?

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b. During a cholera outbreak in a war-devastated country, records for one hospital were examined for the survival of children contracting the disease. These records also reported the children’s nutritional status. Was there a significant relationship between their nutrition and survival rate?

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c. Samples were taken from a specific batch of drug and randomly divided into two groups of tablets. One group was assayed by the manufacturer’s own quality control laboratories. The second group of tablets was sent to a contract laboratory for identical analysis.

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d. An instrument manufacturer ran a series of tests to compare the pass or fail rate of a new piece of disintegration equipment. Samples were taken from a single batch of uncoated tablets. Two different temperatures were used and tested for compendia recommended times. Success was defined as all six tablets disintegrating in the disintegration equipment.

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e. Three physicians were selected for a study to evaluate the length of stay for patients undergoing a major surgical procedure. All these procedures occurred in the same hospital and were without complications. Eight records were randomly selected from patients treated over the past twelve months. Was there a significant difference, by physician, in the length of stay for these surgical patients?

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f. Acme Chemical and Dye received from the same raw material supplier three batches of oil from three different production sites. Samples were drawn from drums at each location and compared to determine if the viscosity was the same for each batch.

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g. Two different scales were used to measure patient anxiety levels upon admission to a hospital. Method A was an established test instrument, while Method B (which had been developed by the researchers) was quicker and an easier instrument to administer. Was there a correlation between the two measures?

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